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According to references, the current routes or reaction steps are evaluated whether it is suitable for scale-up in material cost, safety, timeline, operability, etc.
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The synthesis routes are designed and explored by experienced chemists.
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Several routes are pushed ahead in parallel for route exploration, and related research teams stay in close communication on updated reaction information and do flexible routes adjustment, avoiding losing any possible better route.
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The optimum route is quickly screened for the subsequent process development by multi analytical means such as LC-MS, GC-MS and NMR.
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Key steps are screened and optimized by simultaneous reaction station and high throughput screening platform.
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New process chemistry technologies are widely used to enable the chemical transformations of high challenge or harsh reaction conditions.
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More than 20 years' experience of hazardous chemicals use and production support the synthesis route development.
